Organon §132

However, when one wants to investigate only the symptoms themselves (especially of a weak-powered medicinal substance) without regard for the sequentiality of the befallments or the duration of the medicine’s action, the preferred arrangement is to administer a dose that is heightened [i.e. , given in greater quantity] every day for several days in a row. Then the action of even the mildest, as-yet-unknown medicine will come to light, especially when it is tested on sensitive persons. 

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