Organon §131

The action of a medicine is less clear when a prover must take increasing doses on successive days.

If however, in order to experience anything at all, one must give, as a test, the same medicine in ever-heightened doses [i.e. , an increased amount of globules] to the same person several days in a row, then to be sure, one experiences the various disease states which this medicine can in general bring to pass, but not their sequence. Also, the subsequent dose often curatively takes away one or another symptom aroused by the previous dose; or it takes away symptoms in bringing forth the opposite state. These symptoms must be bracketed as ambiguous until subsequent purer tests show whether they are counter- and after-actions of the organism or reciprocal actions of the medicine.