Organon §199

If the local symptom has been annihilated by a caustic or dessicative external treatment or by surgery (because the remedy appropriate for the disease had not yet been found) 180 then the case becomes far more difficult.This is because the symptoms that remain are too indefinite (uncharacteristic) and inconstant, and the external main symptom (the one that would have been best able to guide and determine the selection and internal application of the most apt remedy, up to the point of the entire annihilation of the disease) has been withdrawn from our observation. 


180 This was the situation before I discovered the remedies for figwart disease (and the antipsoric medicines).