Organon §250

A poorly selected medicine should be replaced by the most appropriate homeopathic remedy for the present disease state.

In urgent cases, after six, eight or twelve hours, it may already be revealed to the sharp-sighted medical-art practitioner who accurately investigates according to the disease state, that he has mis-selected the medicine last given. The patient's state grows distinctly (even if only ever-so-slightly) worse from hour to hour, as new symptoms and ailments arise. In these cases, it is not only permitted but the physician is duty-bound to make good the mistake he has made by selecting and administering a homeopathic remedy which is not merely tolerably fitting, but which is the most appropriate possible for the present disease state [i.e. , the disease state as it now appears, with the old symptoms that remain and the new symptoms] (§167).