Organon §223

But if the antipsoric (and possibly antisyphilitic) treatment is not given, then we can almost assuredly expect a new, more prolonged and bigger attack, from a much slighter occasion than with the first appearance of the insanity. During this new attack, the psora is wont to develop itself fully and turn into either a periodic or a constant mental derangement, which is then more difficult to cure with antipsorics.