Organon §167

If significant new symptoms arise from the first imperfect medicine, do not wait for the medicine to finish its work. Select a second medicine based on the new disease image formed by the remaining original symptoms and the newly arisen ones.

In cases of acute disease, if accessory ailments of some moment arise with the use of this first-employed, imperfectly homeopathic medicine, one should not let this first dose fully finish its work, abandoning the patient to the medicine's full duration of action. Rather, one should examine anew the now altered disease state and bring the original symptoms that remain into connection with the newly arisen ones in order to record a new disease image.

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