Organon §130

Provings made with only one dose provide information about the order in which symptoms appear. The duration of a medicine’s action can only be ascertained from several experiments using only one dose.

If, right at the outset, a properly strong medicinal dose has been administered, then one has the advantage of being able to record the exact sequence of symptoms that the prover experiences, and the times when each appears. This is very instructive for knowledge of the medicine’s character because the order of the initial actions, and also the reciprocal actions, comes to light most unambiguously. Even a very moderate dose is often sufficient for the proving if the prover is fine-feeling enough and very attentive (as much as is possible) to his condition. The duration of a medicine’s action only becomes known through the comparison of several tests [in which only one dose is taken].  

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