Organon §113

Narcotics may have a perceptible counter-action even in moderate doses.

The narcotic medicines appear to be the only exception in this regard. During the initial action, partly they take away the sensitivity and sensibility, and partly they take away the irritability. Then, even with moderate test doses in healthy bodies, a heightened sensitivity (and greater irritability) is frequently noticeable in the after-action.  

 

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